Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC
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Are you sure you want to delete your template? Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization.
SAFETY DATA SHEET - Fisher Sci Chemical Formula: (C6H10O5)n 1.4. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest.
Microcrystalline Cellulose / Avicel PH-102 - Chemical - Stobec II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone.
Microcrystalline Cellulose MSDS - Newseed Chemical Co., Limited Microcrystalline cellulose, a direct compression binder in a quality by It . Watch Now. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b : 5. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC .
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XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. These, in turn, are assembled into fibrils in the cell wall. EMCOCEL 90 M. 130. PharmaCentral 2021 . Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. Buy Chemicals. Microcrystalline Cellulose. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Product and Company Identification . Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . 1 0 obj
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Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Origin(s): Plant/Botanical. Terms and Conditions Compliance Solutions Industries About 3E News & Events .
List of Microcrystalline Cellulose Products and Manufacturers endobj
Molecular weight: Not Applicable 1.5. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. "l%I-*j|-)@
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?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. . Document(s): certificate data msds. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. : 160182 Date Approved: 05/25/2010 Revision No. Product Name: Microcrystalline Cellulose E460 1.2. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Regulatory Information Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. X\o^ Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Earth Supplied Products LLC.
Microcrystalline Cellulose Market Forcast 2023 To 2028 : In-depth BIOACCUMULATIVE POTENTIAL Heavy metals, % NMT 0.001 Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER 1.3. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements.
microcrystalline cellulose melting point FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. %PDF-1.4
: 51395-75-6 Date Approved: 01/31/2008 Revision No. Performing this action will revert the following features to their default settings: Hooray! <>
Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. . Eur., JPE . MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine } !1AQa"q2#BR$3br Remove SUBSTANCE IDENTIFICATION 1.1. 3 0 obj
PDF MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Your file is uploaded and ready to be published. stream
Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Watch Now. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR
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PDF Safety Data Sheet - Accentuate SUBSTANCE IDENTIFICATION 1.1. l~5C
Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Avicel PH-200 microcrystalline cellulose NF, Ph.
PDF Material Safety Data Sheet - FMC Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138.
PROSOLV SMCC - JRS Pharma Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . endobj
In large quantities it provides dietary bulk and may lead to a laxative effect.
PDF Material Safety Data Sheet Material safety data sheet - FMC Corporation - YUMPU : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Learn about FMC's industry leading goal of net-zero emissions by 2035. %PDF-1.5
Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. 6 0 obj
Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. X]s
;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. endobj
It is a white, free-flowing powder. SCMm_>x^O9l (n. stream
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Characterisation of the interactive properties of microcrystalline With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. <>
Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. An agricultural sciences company. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15.
PDF Safety Data Sheet - Parchem (PDF) Commercial sources of "Avicel RC/CL" and its - ResearchGate w !1AQaq"2B #3Rbr CAS #: 9004-34-6 . bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O However, if handling bulk powders, observance of appropriate safeguards is recommended. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. %PDF-1.4
More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. It is hygroscopic and insoluble in water. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. However, it yields non-digestible fibre.
MATERIAL SAFETY DATA SHEET - Sevron Powder becomes slippery when wet. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA
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Global Microcrystalline Cellulose Market (MCC) Size Will Reach US$ 1360 AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. FMC Corporation. All rights reserved. If you are already a ChemPoint customer then sign up for access to our online ordering website.
A family of polysaccharide products that allow distinctive drug delivery solutions. EMCOCEL XLM 90. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Cellulose microcrystalline for column chromatography. However, consumption of large quantities of the material may have a laxative effect. CAS 9004-34-6. q86@on$^X_HuH;3`
Excipients for Pharmaceuticals | Products | IFF - DuPont Have an order or account question, find answers in our Online Support articles. endobj
ChemicalBook. Avicel PC 611 (FMC Biopolymer) . LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. MATERIAL SAFETY DATA SHEET. "R}~Q:~pgg'"l/O:OV~
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The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. 51395-75-6 Avicel RC 591. Looking for FMC'searnings news? Microcrystalline Cellulose / Avicel PH-102. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. 0.25 - 0.37. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER
FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information)
FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. 4. 6 The cellulose molecule is formed through repeated condensation of cellobiose units. Avicel Microcrystalline Cellulose Physical Properties. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. MSDS Ref. Validity Area. Microcrystalline Cellulose Side Effects. ). 1 0 obj
They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. q9;v80 Explore how you can develop your career and bring your creative ideas to life at IFF.
PDF PRODUCT OVERVIEW: Avicel PH-200 - Signet HMo@9, U Q!R/1*;`
PDF Pharma Solutions Avicel Co-Processed Product Selection Guide - DuPont Protect them from sunshine or rain.
MATERIAL SAFETY DATA SHEET - Sevron Avicel RC-591 & CL-611 - Description. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. CoA. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Synonyms: Cellulose, Cellulose powder, Cotton linters. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12.
Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Page 1 of 8. 5 0 obj
Fiber supplements can lessen the absorption of some . DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. /Contents 4 0 R
As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Van Veen, G.K. Bolhuis, Y.S. No. pfTr^i5wOg)y .6
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{vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. : 160182. MCC helps in the formation of spheres because of its . Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends.
Avicel PC 611 (FMC Biopolymer) | CosmeticsAndToiletries.com Combines good flow and high compactibility. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 .
Avicel CL-611 Microcrystalline Cellulose and - FMC - YUMPU The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. <>
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. Avicel PC 611 Microcrystalline Cellulose. Microcrystalline cellulose is a commonly used excipient in the . No.
408. Microcystalline cellulose (WHO Food Additives Series 8) The typical mean particle size is 20200 m. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork,
AVICEL RC 581 at Rs 140/kg | Pharmaceutical Excipients in - IndiaMART The table below shows the most common physicochemical parameters of this raw material. : CL-611NF Date Approved: 01/13/2010. 0.25 - 0.37. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. By producing Avicel . Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Safety Data Sheet for Cellulose microcrystalline 102331. Instead, they obtained a stable colloidal suspension. 2008-2023 ChemPoint.
Lattice Microcrystalline Cellulose, DuPont - ChemPoint Truly distinctive drug delivery solutions. 1 0 obj
Microcrystalline Cellulose - an overview | ScienceDirect Topics Revision No. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used.
Global Wood Pulp Based Microcrystalline Cellulose Market - Industry Reports Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . cas:9000-11-7 msds Carboxymethyl cellulose. Explore how we work and why we apply science and creativity for a better world to everything we do. Gloves, eye protection and a dust mask should be used. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used.
Cellulose microcrystalline CAS 9004-34-6 | 102331 - EMD Millipore The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). CAS 9004-34-6, pH 5 - 7.5. Avicel PH-101. Microcrystalline Cellulose NF. ( %
FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. There may be more fiber in your food than you realized. (&E. There have always been two different points of view for the liquidity of MCC. Wu, K. Zuurman, H.W. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets.
Microcrystalline Cellulose (MCC) Manufacturing | Pharmaceutical Grade ]2}Sb2Wdn-;^}n(/;r\'l3--l~
kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Report Category. Manufactured by: China . These grades have particle sizes ranging from <30 to approximately 200.
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